How is a Coronavirus Diagnosed in a Patient?
There are two types of coronavirus tests. If you get a blood sample, it means that the antibodies present in it will determine if your body has a virus.
If you have a swab test, you will get a sample from your mouth which is suitable for ‘polymerase chain reaction’ or PCR test. Most tests are taking place in Pakistan with similar kits.
Dr. Huma points out that the sample obtained from any individual in the PCR test is compared with a ‘Non-control’. ‘Non-control’ refers to the genetic sequence of the virus that is identified.
According to them, when the two samples are compared, the pattern that is similar to the genetic sequence of the coronavirus is considered positive.
If the genetic sequence of the sample does not match the sequence of the virus coming from Wuhan, China, it means something else and the test results in a negative.
‘COVID-19 virus is a virus similar to SARS, which already exists in different places, has its own structure. In addition, it is said about the virus that when it is transmitted from one person to another it changes its shape. ‘
But can the test result be wrong?
Is it possible for a person to come to the Coronavirus test negative and they are diagnosed with Corona in their body after death?
According to Dr. Huma, the error in the PCR test is very low if the sample is taken correctly. According to him: “If the patient is not sampled correctly or the amount is less than the need, then the false negative can occur.”
However, if the test comes out positive, the error is less likely because a positive result will only come from the genetic sequence of the virus in the PCR test.
What’s the difference between False Positive and Positive Negatives?
Gomal University’s Center for Biochemistry and Biotechnology Dr. Muzamil Ahmad Khan says falls positives usually occur at occasions where a patient’s sample is either contraindicated (ie, not pure), or for a test. Devices must be contaminated or mistakenly coupled with a positive sample to another sample.
If the person receiving the sample is the virus or the person who is doing the test is infected, the error can still be positive.
According to Dr. Muzmal, one of the causes of falls negative may be the reduction of viral load. This means that the virus is low in the patient.
According to him, it is possible that in normal PCR tests, samples of patients with low viral load should be declared negative and when tested on more sensitive devices they will come out positive.
Dr. Muzammal claims that there have been cases in China where a patient’s ‘real-time polymerase chain reaction’ test or RTPCR test came out negative but a more sensitive digital ‘droplet chain reaction’ test. Or the virus was diagnosed in the same sample with the DDPCR test.
Report on Coronavirus: How Does COVID-19 Test In Pakistan?