According to a report of the Children’s Hospital of Lahore, an institute of genetic tests and surveys in Pakistan, 60 to 70 percent of children with various diseases across the country have found that the disease has inherently transmitted.
In this regard, An awareness seminar was organized by the Department of Pediatrics and Liver of Children’s Hospital, Lahore, on February 29, in honor of the World Day for Rare Diseases.
It is the only institution in Pakistan that provides genetic testing for children with fatal diseases free of charge.
Recently, 2,000 families from across the province were tested in connection with this organization’s genetic report, As a result, it turns out that children born as a result of marriages within the family or caste community are at an alarmingly high rate of genetic diseases.
According to Professor Huma Arshad Cheema of the Children’s Hospital, tests from 60 to 70 percent of children with various diseases across the country have found that the disease has inherently transmitted.
According to the report, most of the children suffering from the disease were those whose parents were married within the family or within the same caste community.
Hereditary diseases are commonly seen in more children of Aara’in, Rajput, Baloch, and Jat community in Punjab, However, in Khyber Pakhtunkhwa, those children from Peshawar, Malakand, and Waziristan also looked more affected, Where it is customary to get married in the family.
According to the report, due to marriage in cousin marriage or community without conducting a genetic test In children, deadly diseases, including heart, kidney, liver, and brain diseases, are transmitted through genes.
Dr. Huma Arshad Cheema told The Independent Urdu in an interview The transmission of malignant diseases in children through genes has increased alarmingly, and the mortality rate for these diseases has also risen to 60%.
Dr. Huma believes that families in which children are married should perform genetic tests first so that they can be estimated. That their genes were not transmitted to children and they would not inherit any disease.
sHe, along with her team, took blood samples of siblings, parents, and other bloodied relatives of children treated with deadly diseases, she added. Which found that in most children who died of the disease at one year of age, the disease was transmitted by the parent.
She said that if the family’s medical details were collected, then the hereditary diseases in children would be immediately diagnosed.
In Pakistan, it is inevitable to control the growing deadly diseases in children through genes. However, no significant progress has been made towards resolving the issue at the government level.
Dr. Huma Arshad Cheema says they have sent recommendations to the health department twice on the issue. No major hospital in Pakistan does genetic testing however, treatment is provided only at the diagnosis of the disease.
Patients from remote areas have to come to Children’s Hospital Lahore for genetic tests from across the country, she said. and these tests cost from Rs 6 to 8 lakh, so no hospital is serious about creating this kind of lab.
According to Dr. Huma, she has suggested to the government that the Institute of Research and Genetic Center be established in Lahore for Punjab, In order to research about it separately, tests should be done and a prevention strategy can be devised.
Genetic diseases are being explored not only in Pakistan but all over the world.
A survey was done in the UK last year called ‘Deciphering Developmental Disorders’ (DDD), using the latest technologies available. This study may be called the largest genetic survey of pediatric disorders.
More than 20,000 genes have been carefully studied by 200 geneticists from the UK’s National Health Service (NHS) in DDD.
The key experts in this research at the Wellcome Trust Sanger Institute in Cambridge are Dr. Matthew Hurles and Jeremy McRae.
Experts studied the genes of four thousand 293 families for this, and it turned out that they had some genetic disorder.
Exosome sequencing was used to conduct this study, in which those areas of human DNA are seen Which produce proteins that can cause some kind of disease or syndrome.
The results of this survey were also reviewed clinically and compared with thousands of pre-existing cases, leading to the finding that over 4 million children in the United Kingdom suffer from congenital disorders and diseases annually. The cause is hereditary.
Report on Cousin-Marriages And The Risk Of Genetic Disease